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What’s the deal

2018 M&A activity in life science Scandinavia

By | Business Development, Valuation, What's the deal | No Comments

During 2018, 12 life science mergers and acquisition (M&A) deals took place in Scandinavia for a total value of $11.5 billion. After a year with several inbound and outbound deals, we can conclude that Scandinavian life science companies beyond doubt are becoming more and more established in the world. But in which areas and within which fields are these deals taking place? To answer this question, we took a deep dive into the 2018 M&A activities of the Scandinavian life science industry!

Life science is a broad field, where companies can be divided into four different subsectors that include biotech, pharma, medtech and healthtech (see Figure 1). The biotech sector is the largest of them (total of 58%) and is in turn divided into four subsectors. Given the market size, it is unsurprisingly also the sector with most M&A deals. Following this is the medtech sector, which makes up almost one-third of the life science industry (29%) and bore the largest valued M&A deal in 2018.

In total, the Scandinavian life science industry comprises more than 1,330 companies (see Figure 2), where most companies are located in Sweden (65%), followed by Denmark (20%) and then Norway (15%). Due to the innovativeness and quality products/services developed in this region, these companies represent potential opportunities for M&A deals in the life science Industry.

Note: This is an analysis of selected M&A or asset acquisition deals with publicly disclosed deal values. Deals with undisclosed values have not been included.

Sweden

Sweden is Scandinavia’s largest country in terms of landmass, population and number of life science companies. Only in 2018, Swedish companies spent about $492.4 million (see Table 1) on the acquisition of other companies or assets, where 96% was spent in international companies or assets and 4% remained within national boundaries. In terms of inbound deals, only two Swedish companies were acquired. The total sum of these acquisitions amounted to $860.6 million, where the majority stems from the American company Alexion Pharmaceuticals’ acquisition of Wilson Therapeutics for $855 million.

Swedish M&A in 2018

Acquirer Acquired Assets/services involved Total deal value
Biotage (Sweden)* Horizon Technology (US) Provider of systems and consumables for separation in water purification, food safety, petrochemical industry, biofuels, agriculture and the pharma industry $17.9 million
AddLife (Sweden) Wellspect HealthCare (Sweden) Business in surgery and respiration $20 million (€18 million)
Biotage (Sweden) PhyNexus (US) Dual flow chromatography and patented tip technology for higher throughoutput purification $21.5 million
Recipharm (Sweden) Sanofi (France) Manufacturing center and business in respiratory diseases $58 million (GPB 45 million)
Recipharm (Sweden) Nitin Lifesciences (India) Pharma company with strong presence in injectable manufacturing $86 million (824 million SEK)
Karo Pharma (Sweden) Leo Pharma (Denmark) Product portfolio in infection, cardiovascular and dermatology $289 million (€260 million)
Ultimovacs (Norway) Immuneed (Sweden) Immunotherapy technology business $5.8 million (50.4 million NOK)
Alexion Pharmaceuticals (U.S.) Wilson Therapeutics (Sweden) Novel therapies in rare copper-mediated disorders, including WTX101 product $855 million (7.1 billion SEK)

 

Denmark

Denmark (Greenland exempted) is a small country with a high density of life science companies. From the selected deals in 2018, Danish companies spent about $1.8 billion in the acquisition of other European companies or assets. In terms of inbound deals, three Danish companies were acquired for a combined value of a hefty $8.6 billion. The deal between Widex and Sivantos alone was valued at $8.3 billion and is considered the largest M&A deal in Scandinavia during 2018.

Danish M&A in 2018

Acquirer Acquired Assets/services involved Deal value
Novo Nordisk (Denmark) Ziylo (UK) Science incubator (including glucose binding molecule platform) $800 million
Lundbeck (Denmark) Prexton Therapeutics (Netherlands) Foliglurax in the treatment of Parkinson’s disease $1 billion (€905 million):
Virtus (Australia) Triangeln Fertility Clinic/ Fertilitetsklinikken Trianglen (Denmark) Treatment of fertility $30 million (202 million DKK)
Karo Pharma (Sweden) Leo Pharma (Denmark) Product portfolio in infection, cardiovascular and dermatology $289 million (€260 million)
Sivantos Group (Germany)* Widex (Denmark) Hearing aids $8.3 billion (€7 billion)

Norway

Norway has the highest GDP per capita and is known for its innovativeness and openness to new technologies. As an example, Norway was the first Scandinavian country to approve a CAR T-cell therapy (gene therapy): Luxturna. In 2018, only one acquisition deal with disclosed values was identified. This deal was Ultimovacs’ acquisition of the immunotherapy technology business Immuneed for $5.8 million.

Norwegian M&A in 2018

Acquirer Acquired Assets/services involved Deal value
Ultimovacs (Norway) Immuneed (Sweden) Immunotherapy technology business $5.8 million (50.4 million NOK)

Concluding thoughts on an increasingly stronger life science field

The M&A and asset acquisition scene of Scandinavian life science companies is on fire with several large cross-border deals taking place in 2018. Acquisitions performed by American, Australian and European companies strongly signal Scandinavian companies’ international reach. Nevertheless, there were more outbound than inbound deals involving Swedish companies suggesting that Swedish companies may often both be financially healthy, and business savvy, to expand their operations and presence internationally. Denmark, on the other hand, is home to the big and internationally established companies such as Novo Nordisk and Lundbeck. Therefore, it is not surprising that these companies performed high-value deals with other European countries. Furthermore, a major oncology cluster is located in Norway and this means that over the next couple of years, we may continue to see inbound and outbound oncology-related M&A deals in this country.

Companies in Sweden are often both financially healthy, and business savvy, enough to expand their operations and presence internationally.

Based on the high concentration of life science companies located in Scandinavia, we may continue to see an increasing number of M&A deals in these sectors. Although the majority of acquisition deals belonged to biotech companies, especially those developing therapeutics, the highest valued M&A deal in 2018 took place between the two medtech companies Sivanto and Widex. Medtech companies have a shorter time to market and when these companies reach the market and become established in the market, the acquisition value increases. Thus, this is a perfect example of how more mature innovative companies are valued higher in an M&A, whereas high risk early stage companies, such as those developing therapeutics, are valued slightly lower in upfront payments, and oftentimes include milestone payments and/or potential royalties to leverage risk and compensate for their high valuation.

Finally, the healthtech sector is still in an embryonic stage and it is just starting to blossom. For example, the company Tunstall Healthcare acquired Danish company EWii Telecare for connected healthcare products and tele-medical solutions for various patient groups. This sector should not be underestimated since the whole field is moving more towards personalized and connected healthcare. Therefore, it will not be a surprise if the number of deals in this sector increases in the upcoming years.

By: Paola Jo, Management Consultant

The neglected sclerosis: Primary progressive multiple sclerosis

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On World MS Day, May 30, a light is cast upon the hidden symptoms of multiple sclerosis (MS) and the disease’s significant, but often invisible, impact on a patients’ quality of life. This impact is especially burdensome for patients with the disease type primary progressive multiple sclerosis (PPMS) who do not experience active and inactive periods of the disease but rather a progressive loss of neurological function. Still, there is only one treatment for these patients to turn to, a treatment that made impressively 2.4 BUSD in sales last year. With such an interesting case in front of us, we could not help but ask: what’s the deal with PPMS?

MS is the most common inflammatory disease in the central nervous system, affecting more than 2 million people worldwide. The disease occurs when the body’s immune system attacks the myelin, a protective insulation around nerve cell axons, due to an unknown reason. When the myelin is damaged, the transmission of information via nerves is hindered. At presentation, typical symptoms of MS include vision loss, limb weakness, sensory loss and ataxia.

MS is the most common inflammatory disease in the central nervous system, affecting more than 2 million people worldwide. The disease occurs when the body’s immune system attacks the myelin, a protective insulation around nerve cell axons, due to an unknown reason. When the myelin is damaged, the transmission of information via nerves is hindered. At presentation, typical symptoms of MS include vision loss, limb weakness, sensory loss and ataxia.

There are four types of MS, which include relapsing-remitting MS (RRMS), secondary-progressive MS (SPSM), primary-progressive MS (PPMS) and progressing-relapsing MS (PRMS). Today, around 1015% of all MS patients have PPMS, a condition that has a a gradual but steady progression of neurological disability. The UK patient organization the MS trust states the common symptoms of more advanced PPMS are difficulty walking, fatigue, bladder and bowel problems. RRMS is the most common form of MS affecting 80% of all MS patients, and causes fully or partially reversible episodes of neurological disability, i.e. MS episodes.

These patients [PPMS] will not experience the RRMS associated MS episodes, but instead a gradual but steady progression of neurological disability.

An unknown disease pathology hindering therapeutic advancement

Patients diagnosed with PPMS are facing a worse prognosis than RRMS patients, but the group has often been neglected in terms of both general scientific research and clinical trials. A result of the neglection is that the underlying pathology of the disease still is unclear, which makes the development of effective therapeutics a significant challenge. Unfortunately, the majority of RRMS treatments are aimed at decreasing the number of or impact of relapses, which PPMS patients do not experience and thus cannot benefit from.

Over the last couple of years, a number of both Big Pharma and smaller life science companies have approached the PPMS field but failed due to a lack of efficacy compared to placebo.

The first disease-modifying treatment

In March 2017, Genentech obtained FDA approval for Ocrevus (Ocrelizumab), the first and only disease-modifying therapy for PPMS. In August of 2018, the drug was granted approval also in the EU under its European owner Roche.

While Ocrevus has been approved in more than 70 countries for the treatment of PPMS and RRMS, far from all patients are likely to benefit from the treatment. The Swedish authority for drug recommendations, NT-rådet, wrote in their statement regarding Ocrevus that the drug’s effect on the primary efficacy variable “time to progression of disability” was small, and that the reliability of the scientific documentation was moderate as the population in the trial did not reflect the actual PPMS population. The demand of effective therapies for PPMS thus remains a major unmet need in the MS treatment landscape. When the UK’s The National Institute for Health and Care Excellence (NICE) initially chose not to recommend Ocrevuz as a reimbursable treatment for PPMS, meaning it would not be covered by National Health Service (NHS), outrage followed. This did not only urge the NHS to strike a commercial in confidence deal with Roche lowering the treatment cost and thus paving the way for NICE to change their decision, but it also demonstrates the power of PPMS patients.